Alana Welm
The research in my laboratory is focused on the mechanisms of breast tumorigenesis and metastasis, where we have developed new, complementary in vitro and in vivo approaches to gain a better understanding of this process. Using these methods, we discovered that the Ron signaling pathway is an important facilitator of breast cancer metastasis. Our current areas of research include:
1. Mechanisms by which Ron and short-form Ron promote metastasis, including the role of Ron in anti-tumor immunity
2. Mechanisms by which Ron signaling preferentially induces breast cancer metastasis to bone
3. Pre-clinical studies of Ron inhibitors for treatment of metastatic breast cancer
4. Development of innovative mouse models for improved prediction of drug response in breast cancer, including our published patient-derived breast tumor graft models.
Abstracts this author is presenting:
