Friday, 13th February

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Speakers

8:30AM - 10:30AM

Novartis Lecture Theatre

Chair: Mark Smyth

Targeting melanoma with autologous peripheral blood GD2-specific chimeric antigen receptor T cells - Michael Brown
License for Destruction: Tumour-specific Cytokine Targeting - Ruth Ganss
Inducible but not constitutive expression of PD-L1 in human melanoma cells is dependent on activation of NF-κB - Kavitha Gowrishankar
Beyond Mendel: the complex, polygenic genetic architecture of sarcoma risk - David Thomas

10:30AM - 11:00AM

Friday, 13th February

Exhibition Hall

11:00AM - 1:00PM

Friday, 13th February

Novartis Lecture Theatre

Chair: Mark Shackleton

Characterising the Cancer Genome in Plasma - Sarah-Jane Dawson
Novel approaches to targeting the tumour-stroma coalition in triple negative breast cancers - Aurélie Cazet
Breast cancer and metastasis: new insights into BCL-2 family members - Delphine Merino
Ron kinase as a target for immunotherapy in breast cancer - Alana Welm

1:00PM - 4:00PM

Friday, 13th February

Exhibition Hall

4:00PM - 6:10PM

Friday, 13th February

Novartis Lecture Theatre

Chair: Jonathan Cebon

Tumor heterogeneity in melanoma progression and therapy - Claudia Wellbrock
miR-514a regulation of NF1and resistance to PLX4032 targeted therapy of melanoma - Mitchell Stark
Mast cell protease 4 protects against chronic ultraviolet B-induced skin tumourigenesis. - Houng H Taing
Investigating the role of the NR4A3 orphan nuclear receptor in DNA repair and stress response in melanocytes and melanoma cells - Kelvin Yin

6:00PM - 7:30PM

Friday, 13th February

7:30PM - 10:00PM

Friday, 13th February

Exhibition Hall

miRNA-124 Expression Correlates with Epigenetic Treatment Response in Myeloid Malignancies - Hongbin Liu
Investigating the role of mutant P53 in the development, growth and chemosensitivity of lymphoma - Brandon Aubrey
An investigation into the causes of genetic translocation events in prostate cancer - Michael Clarkson
Novel Benzoxazines as Angiogenesis Inhibitors - Terri Meehan-Andrews
Combination of Doxorubicin and targeted therapies (DNA-PK and Bcl-2 family inhibition) to improve the outcome of breast cancer treatment - Terri Meehan-Andrews
C-C chemokine receptor 5 (CCR5) is required for tumor angiogenesis. - Albert S Mellick
The role of myeloid cells in breast cancer metastasis - Kellie Mouchemore
Flightless I expression affects tumour growth - Noraina Muhamad Zakuan
Hassle Free Assay Development Through the Use of Avidity Binding Metal Chelation Surface Coating - Dean Jennins
The Inhibitor of Differentiation proteins mediate tumour-initiating properties and metastasis in breast cancer - Radhika Nair
Regulation of sphingosine kinase 2 by a novel interaction with the dynein complex - Heidi Neubauer
Using E7 immunohistochemistry to show high risk HPVs probably have oncogenic influences in a subset of breast cancers. - Christopher Ngan
Harnessing functional genomics to study the role of microRNAs in cancer chemosensitivity - Iva Nikolic
OLIGO-ADENYLATE SYNTHETASE-2 (OAS2) INFLUENCES LACTATION, PRIMARY MAMMARY TUMORIGENESIS AND LUNG METASTASIS. - Samantha R Oakes
Immune-evasion targets in therapy-resistant advanced melanoma - Aleksandra M Ochnik
Laminin-511 And Its Integrin β4 Receptor Promotes Breast Cancer Metastasis Through Modulation Of Epithelial To Mesenchymal Transition - Selda Onturk
Defective Intra-S Cell Cycle Checkpoint: A Potential Culprit and Target in Melanoma - Zay Yar Oo
miR-204 is a novel target of MYCN and potential tumour suppressor in neuroblastoma tumorigenesis - Chi Yan Ooi
LOCAL INFLAMMATORY RESPONSE TO SYNCHROTRON RADIATION - Jason S Palazzolo
Genomic Archeology Reveals the Origins and Evolution of Cancer Neochromosomes - Tony Papenfuss
βIII-Tubulin influences multiple stress responses and Akt signalling to promote cell growth and survival in glucose starved Non-small Cell Lung Cancer. - Amelia Parker
Potential markers for metformin susceptibility in colorectal cancer - Adam C Parslow
Evaluating genetic and epigenetic tumour cell heterogeneity in colorectal cancer - Marie Parsons
Involvement of the E6AP-PML axis in prostate cancer and its potential use for therapy. - Piotr J. Paul
Using a Novel Peptide to Target Tumour Angiogenesis - Prue Plummer
Efficient immunomagnetic isolation of circulating ovarian tumour cells - Joseph Po
Haematopoietic Cell Kinase Activation Promotes IL-11 Dependent Gastric Cancer Progression and Invasion in Mice - Ashleigh Poh
β₂-adrenoceptor signalling promotes invasion of human breast cancer cells - Cindy K Pon
A survey of cis-regulatory mutations identifies a potential driver mutation in the promoter of NDUFB9 in metastatic melanoma - Rebecca C Poulos
Pregnancy-Associated Plasma Protein-A links pregnancy and melanoma progression by promoting cellular migration and invasion - Prashanth Prithviraj
THE INTERPLAY BETWEEN MUTANT p53 AND PML IN CANCER CELLS - Tahlia Procter
A ROLE FOR E6AP IN THE REGULATION OF p27 IN PROSTATE CANCER DEVELOPMENT AND PROGRESSION. - Dinesh Raghu
ESTABLISHMENT OF A CLINICAL RESOURCE TO EVALUATE BIOMARKERS TO SYSTEMIC THERAPIES FOR MELANOMA PATIENTS - Jeanette Raleigh
Characterising oncogene-driven glycolysis as a therapeutic target in NRAS-mutant melanoma - Aparna D Rao
The dual role of complex I subunit NDUFA13 (GRIM19) in life and death: An analysis through TALEN-mediated gene disruption - Boris Reljic
Patient-Derived Xenografts Reveal Intraductal Carcinoma of the Prostate is a Prominent Pathology in BRCA2 Mutation Carriers with Prostate Cancer and Correlates with Poor Prognosis - Renea Taylor
Polysaccharopeptide activates monocytes in resting human peripheral blood mononuclear cells: Immunomodulatory implications for cancer treatment - Rebecca H Roubin
Pandora's box and the next generations of DNA sequence data. - Stephen Rudd
Identification of dysregulated microRNAs in soft-tissue sarcomas through integrative expression analysis - Regina Ryan
Analysing the impact of deleting CARD containing caspases on different forms of cell death - Ranja Salvamoser
A novel E2F/sphingosine-1-phosphate axis drives CRM1-dependent nuclear export of E2F7 and resistance to anthracyclines in squamous cell carcinoma - Nicholas Saunders
Phenotypic switching of FcR-dependent sensitivity to therapeutic antibodies occurs in patients with progressive chronic lymphocytic leukaemia - Nicholas Saunders
A Stress Induced Early Innate Response Causes Multi-Drug Tolerance in Melanoma - Helmut Schaider
Determining the role of the pro-survival Bcl-2 family member Bfl-1/A1 in cancer - Robyn Schenk
Identifying novel cancer cell susceptibilities - David Segal
A NOVEL STRATEGY FOR SPECIFIC DELIVERY OF siRNA TO CANCER STEM CELLS - Hadi Shamaileh
Identifying primary targets of vitamin D in breast cancer - Lei SHENG
Neural signaling promotes invadopodia formation to drive breast cancer invasion - Erica Sloan
Investigating a novel role for NR4A orphan nuclear receptors in DNA repair and resistance to BRAF inhibitors in melanocyte and melanoma cells - Aaron Smith
Radioprotection by the combination of DNA binding antioxidants and aminothiol radical scavengers - Jai Smith
Functional genomics of BRAF-driven glycolysis in BRAF^V600melanoma. - Lorey Smith
Dysregulation of Pol I transcription in ovarian cancer - Jinbae Son
New approach to AML therapy: Inhibition of rDNA transcription by CX-5461 - Jirawas Sornkom
A COMBINATORIAL APPROACH FOR TARGETED THERAPY OF TRIPLE NEGATIVE BREAST CANCERS: i-PEPS, CHEMOTHERAPY AND NANOPARTICLES - Anabel Sorolla
An atypical cell cycle checkpoint defect in melanoma: a new therapeutic target? - Loredana Spoerri
Cancer Stem Cells Avoid Immune Recognition By The Down Regulation of MHC-I - Jason C Steel
Sphingosine-1-phosphate receptors direct TNFalpha-induced programmed necrosis in breast cancer cells - Olga Sukocheva
Sphingolipid receptors in breast cancer stem cells - Olga Sukocheva
Simultaneous detection of IL-6 and IL-8 secretion by cells using AlphaLISA and AlphaPlex 545 technology - Margareta Sutija
Development of an early detection system for prostate cancer - Joshua Swift
Functional differences among melanoma cells separated according to pigment content. - Clare G Fedele
Identifying novel inhibitors to STAT3 mediated tumor progression - Fiona Tan
RNAi Screens Identify Regulators of Mutant p53 - Kah Hin Tan
FLT3 inhibitor, AC220, protects haematopoietic progenitors from chemotherapy-induced death - Sam Taylor
K63-linked ubiquitylation of BLM is required for its recruitment to the sites of DNA damage to suppress homologous recombination - Shweta Tikoo
Quantitative assessment of intra-tumour heterogeneity in HER2 positive breast cancer as a predictor of patient response - Anne Trinh
Histone deacetylase and proteasome inhibitors synergistically induce apoptosis in colon cancer, multiple myeloma and CTCL cells through induction of the immediate early gene ATF3. - Janson Tse
Receptor-interacting protein kinase 1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy - Cindy Tseng
Circulating tumour DNA for non-invasive cancer management - Dana Tsui
Phenotypic alteration in a highly metastatic variant of the MDA-MB-231 cell line: role of Annexin A1 - Yan Tu
New generation BRAF inhibitors do not induce paradoxical activation of MAP kinase signalling; implications for therapy - Candani (Dani) Tutuka
Molecular and Cellular Characterisation of Epigenetic Inhibitors - Dean Tyler
Assessing the immune profile of MMTV-HER2neu mice during hyperplasia to identify cells involved in promoting breast cancer development - Ashleigh Unsworth
A novel combination therapy targeting the apoptosis pathway in Diffuse Intrinsic Pontine Glioma - Santosh Valvi
Impact of loss of the transcription factor FoxO3 on Myc-induced tumourigenesis - Cassandra J Vandenberg
Melanoma derived exosomes promote escape from BRAF inhibition by PI3K activation. - Laura J Vella
SYNCHROTRON BROAD BEAM AND MRT RADIATION INDUCES DNA DAMAGE IN NORMAL MOUSE TISSUES DISTANT FROM THE IRRADIATED VOLUME - Jessica Ventura
Improving Cancer Care in the Indigenous Population: A fair distance travelled but still a long road ahead - Ajai Verma
COST AND VALUE OF CANCER CARE: AN EVALUATION OF OUTCOMES IN AN AUSTRALIAN SETTING - Ajai Verma
IL3-Receptor Signaling is Dispensable for the Generation and Maintenance of the Jak2V617F-Induced Myeloproliferative Neoplasm (MPN) - Therese Vu
Cross-presentation of cutaneous melanoma antigen by migratory XCR1⁺CD103^- and XCR1⁺CD103⁺ dendritic cells - Jason Waithman
PASS MNAzyme® qPCR: A novel multiplexing technology for genetic markers of cancer - Samantha Walker
Targeting MEK/ERK and PI3K/Akt to overcome resistance of human colon cancer to HSP90 inhibitors - Chun Yan Wang
Regulation of sensitivity of human melanoma cells to killing by the human Mut T homolog1 inhibitor - Jia Yu Wang
Overexpression of miR-766 up-regulates p53 and represses cell proliferation by reducing MDM4 - Qingqing Wang
Overcoming Resistance of Targeted EGFR/panHER Monotherapy by Inhibition of STAT3 Escape Pathway in Sarcoma - Xiaochun Wang
The Role of IGFBP3 in Glioblastoma Multiforme Progression and Resistance - Thomas MB Ware
Multivariate microRNA expression analysis in cancer by in situ hybridization - David E Wescott
Repurposing drugs and discovering novel chemotherapeutics to target paediatric brain cancer - Jacqueline Whitehouse
3D and monolayer culture systems highlight ABCA1 as a promoter of aggressive characteristics in epithelial ovarian cancer - Rebekka Williams
Associations between mechanisms of BRAF inhibitor resistance and PDL1 expression in BRAF inhibitor treated patient progressed lesions - James S Wilmott
A novel mechanism of cell engraftment revealed by over-expression of the acute myeloid leukaemic stem cell marker IL-3Rα in an in vivo model - Nicole Wittwer
HOW DID THE RED BLOOD CELL LOSE ITS NUCLEUS? - Christina B Woelwer
Catheter resistance monitoring predicts central venous catheter occlusion: Results from a pilot study - Joshua Wolf
Immunotherapeutic potential of the cancer-testis antigen ropporin in melanoma. - Katherine Woods
Epitope Spreading During Adoptive Cell Therapy for Melanoma - Ben Wylie
Aptamer-guided drug delivery for seeking and eliminating the roots of cancer: cancer stem cells - Dongxi Xiang
Defining the role of cohesin in the activation of repetitive DNA in colorectal carcinogenesis - Huiling Xu
Diverse hematopoietic cell types, even normal ones, are readily killed by BET bromodomain inhibitors through Bax/Bak-mediated apoptosis - Zhen Xu
Mitochondrially Targeted Vitamin E Succinate Effectively Kills Tumour-initiating Cells of ErbB2-positive Breast Cancer - Bing Yan
Genome-wide RNAi Screen for Synthetic Lethal Interactions with the Inhibition of RNA Polymerase I in Ovarian Cancer - Shunfei YAN
Discovering the p53 target genes that are critical for p53 mediated tumour suppression - Haoyu Yang
Pathways evaluation: the response of multiple myeloma to standard-of-care agents - Yuan Yao
Effect of EGFR-targeted and metabolic inhibitor combination therapy in sarcomas - Reichelle Yeo
UNCOVERING THE MECHANISMS THAT REGULATE CELL SURVIVAL IN CANCER VIA MANIPULATING THE FUNCTION OF MYELOID CELL LEUKAEMIA 1 (MCL-1) - Adelaide Young
Prevalence and characterisation of tumor infiltrating lymphocytes in head and neck cancer - correlation with clinical outcome and human papilloma virus status - Richard J Young
CIB2 is a negative regulator of oncogenic signalling by sphingosine kinase 1 - Wenying Zhu
Loss of Slit-Robo signalling in the pancreas increases the severity of pancreatitis - Andreia V Pinho
The negative feedback regulator of MAPK/ERK signalling, DUSP5, is methylated in colon cancer. - Lars Togel
Genetically engineered mouse models of proliferative high grade serous ovarian cancer - Matthew J Wakefield
Cancer-associated PTEN mutants act in a dominant negative manner to suppress PTEN protein function - Antonella Papa
QS21 enhances cross-presentation of NY-ESO-I by monocyte-derived dendritic cells in vitro - Anupama Pasam
Metastatic colon cancer cell derived exosomes mediate stromal fibroblast invasion - Alin Rai

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Friday, 13th February 27th Lorne Cancer Conference 2015

Session 3: Cancer Immunology and Immunotherapy

Morning Tea

Session 4: Molecular Targets in Breast Cancer

Lunch

Session 5: Melanoma

Dinner

Poster Session 2